Recent Posts

Incorporating qPCR amplification efficacy and multiple reference genes


Deriving the Diversity Index for the application to antigen arrays.


Een korte beschrijving van het VIRGO project.




Investigating the pathogenesis of dengue and identifying biomarkers.

DC vaccination for HIV

Inducing durable immunity against HIV during chronic infection.

Selected Publications

Profiling the immune responses to chikungunya virus and west-nile virus in mouse brains.
In Frontiers in Microbiology, 2017.

Using a gold-standard dataset and resampling, we evaluated several statistical analysis and imputation procedures for LC-MS/MS data. We show that limma has the highest sensitivity. Imputation reduces sensitivity or inflates the number of false positives. Therefore, we recommend the application of limma on non-imputed data for the analysis of high-throughput proteomics data.
In Briefings in Bioinformatics, 2017.

Respiratory syncytial virus (RSV) causes many cases of severe respiratory tract infection in infants, but predicting which infants go on to develop severe disease and require hospitalization is difficult. Using transcriptome data and support vector machine learning, we describe a 84-gene prognostic signature that separates patients that need high-level medical care from those that don’t.
In Scientific Reports, 2016.

Finding markers for the severity of dengue.
In PLoS Neglected Tropical Diseases, 2015.

Other Publications

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More Publications

. Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic. In Scientific Reports, 2016.

PDF Project

. DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift. In Vaccine, 2015.

PDF Dataset Project

. Hyperferritinaemia in Dengue Virus Infected Patients Is Associated with Immune Activation and Coagulation Disturbances. In PLoS Neglected Tropical Diseases, 2014.

PDF Project

. Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection. In Journal of Clinical Virology, 2014.

PDF Project

. Microbial Translocation Is Associated with Extensive Immune Activation in Dengue Virus Infected Patients with Severe Disease. In PLoS Neglected Tropical Diseases, 2013.

PDF Project