Dengue virus infection typically has mild symptomes, but can also cause hemorrhaegic fever and death in severe cases. Dengue has four serotypes and a secondary infection with a different serotype is associated with more severe symptomes.
In this project, we use - amongst others - transcriptome and proteome profiling to find markers that associate with severe disease.
Publications
Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue
Cornelia A. M. van de Weg, Henk-Jan van den Ham, Maarten A. Bijl, Fatih Anfasa, Fatiha Zaaraoui-Boutahar, Beti E. Dewi, Leonard Nainggolan, Wilfred F. J. van IJcken, Albert D. M. E. Osterhaus, Byron E. E. Martina, Eric C. M. van Gorp, Arno C. Andeweg
Hyperferritinaemia in Dengue Virus Infected Patients Is Associated with Immune Activation and Coagulation Disturbances
Cornelia A. M. van de Weg, Ralph M. H. G. Huits, Claudio S. Pannuti, Rosalba M. Brouns, Riemsdijk W. A. van den Berg, Henk-Jan van den Ham, Byron E. E. Martina, Albert D. M. E. Osterhaus, Mihai G. Netea, Joost C. M. Meijers, Eric C. M. van Gorp, Esper G. Kallas
Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection
Cornelia A.M. van de Weg, Claudio S. Pannuti, Henk-Jan van den Ham, Evaldo S.A. de Araujo, Lucy S.V. Boas, Alvina C. Felix, Karina I. Carvalho, Jose E. Levi, Camila M. Romano, Cristiane C. Centrone, Celia L. de Lima Rodrigues, Expedito Luna, Eric C.M. van Gorp, Albert D.M.E. Osterhaus, Esper G. Kallas, Byron E.E. Martina
Microbial Translocation Is Associated with Extensive Immune Activation in Dengue Virus Infected Patients with Severe Disease
Cornelia A. M. van de Weg, Claudio S. Pannuti, Evaldo S. A. de Araujo, Henk-Jan van den Ham, Arno C. Andeweg, Lucy S. V. Boas, Alvina C. Felix, Karina I. Carvalho, Andreia M. de Matos, Jose E. Levi, Camila M. Romano, Cristiane C. Centrone, Celia L. de Lima Rodrigues, Expedito Luna, Eric C. M. van Gorp, Albert D. M. E. Osterhaus, Byron E. E. Martina, Esper G. Kallas